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However, preliminary data suggests: Tirzepatide: Approximately 33-39% of weight lost was lean mass in SURMOUNT trials Retatrutide: Early data suggests potentially better lean mass preservation, possibly due to glucagon's effects on protein metabolism Regardless of which medication you use, resistance training and adequate protein intake (1.0-1.2g per kg body weight daily) are recommended to minimize muscle loss during treatment
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Rapid dose increases are the leading cause of severe nausea and vomiting in both clinical and real-world use
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